The subject of the GREEN4MED research project is unexplored or insufficiently studied wild and edible plant species characteristic for the Mediterranean area. These are species have developed a range of morphological, physiological, and biochemical adaptive mechanisms that enable them to successfully survive and grow in unfavorable and extreme habitats, such as those exposed to high salinity (halophytes), water scarcity (xerophytes), and high temperatures (thermotolerant species). These adverse abiotic factors are precisely the reason why such species, as a form of defense, produce and accumulate high levels of various bioactive compounds, primarily secondary plant metabolites. The aim of this project is to investigate the phytochemical composition (phenolic compounds, carotenoids, sulfur compounds, and terpenes, depending on the species) of selected wild and edible plant species characteristic of the Dalmatian region, as well as their biological activity (antioxidant, antimicrobial, and enzyme-inhibitory effects, depending on the targeted groups of compounds). During the isolation of these metabolites, special attention will be given to the use of green extraction techniques and their optimization. Selected isolates of chemically characterized samples will be subjected to encapsulation methods (spray drying, lyophilization, ionic gelation) in order to preserve stability and enhance the bioactivity of the isolated active phytometabolites. This will further guide the evaluation of their potential applications in various industries such as the food, cosmetic, and pharmaceutical sectors.